Taxol and taxanes from plants other than Taxus species

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State of art

Taxol® (generic name paclitaxel) is an effective antineoplastic agent employed for the treatment of a variety of cancers that constitute a significant percentage of total cases affecting our population such as ovarian, breast or lung cancer.
Taxol is a rare and highly functionalized diterpenoide plant compound originally extracted from the bark of Taxus brevifolia.
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Objective

We have recently showed that cell cultures obtained from plants different from Taxus are able to produce Taxol and taxanes.
This finding suggested that plants other than taxus possess enzymes involved in the biosynthesis of paclitaxel and related compounds, generally named taxanes.
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Partners

References