MH1C1

Version 4.0.200811

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MH1C1 (rat, buffalo, liver, hepatoma)

Monoclonal continuous culture, grown as monolayer
epithelial morphology
SPECIES: rat, buffalo (male) Karyology: chromosome fragments and breaks
TISSUE/ORGAN: liver
TUMOR: hepatoma
Derived from: Morris hepatoma 7795
tumorigenic in syngeneic animals
Susceptibility to viruses: herpes simplex * vaccinia * vesic. stomatitis (Indiana)
Cell line available under some conditions.
PROPERTIES: serum albumin prod.; serum complement components prod.; monooxygenases expression; tyrosine aminotransferase synthesis; enzymology; metabolism; toxicity screening; cytotoxicity; xenobiotic metabolism; hormone studies

Available in the following LABORATORY:

Istituto Patologia Generale, Universita' degli Studi (GEUCC, Genova)
Ham's F10 + 7.5% NBCS + 10 HS; Freezing medium: Culture medium + 10% DMSO; 37C, 5% CO2, split 1-5 Passage: 70, mycoplasma negative, HOECHST
Chromosome markers: 1 large chromosome with submedian centromere; 1-2 large chromosomes with median centromeres. Derived from hepatoma induced by N-2-fluorenylpthalamic acid.
Validated by: monooxygenase expression and induction

Availability in cell line catalogues: ATCC: CCL 144, ECACC: 85112702, DSMZ: ACC 106, ICLC: ATL98014

Bibliographic references:

Cell Biochem Funct 1988;6:245-250 - PMID: 3191583
Chem Biol Interact 1988;65:629-634
Exp Cell Res 1991;196:330-336 - PMID: 1716586
In Vitro 1970;6:32 - PMID: 4399803
J Cell Biol 1969;40:236-247 - PMID: 4177659
J Cell Res 1969;40:236
Science 1970;170:533 - PMID: 4908238