Version 4.0.200811





Fibroblast collection from patients affected with familial hypercholesterolemia and other metabolic disorders


Skin fibroblasts from a series of patients affected by Familial Hypercholesterolemia (FH) have been collected in the last few years. The following assays are routinely performed on these cells: a) LDL-receptor function; b) Northern blot; analysis of synthesis and intracellular processing of LDL-receptor proteins. From each FH cell line, DNA is also available. Furthermore, dermal fibroblasts from a series of connective disorders, both heritable and acquired, have been collected, from biopsies of the forearm skin or from the affected areas. In all cases, samples were examined by optical and electron microscopy.

Roberta Tiozzo
Laboratorio di Colture Cellulari
Istituto Patologia Generale, Universita' degli Studi
Via Campi, 287
41100 Modena Italy
Phone: +39-0592055422-2055427 Fax: +39-0592055426
E-mail: tiozzorb@unimo.it







For information, get in touch with:

Istituto Nazionale per la Ricerca sul Cancro,
c/o Centro Biotecnologie Avanzate, Torre B - Piano 2
Largo Rosanna Benzi, 10 - I-16132 Genova - Italy Tel: +39-0105558-289, Fax: +39-0105558-293
Email: assunta.manniello@istge.it